壬二酸 for Skin : Know the Basics!

你听说过 壬二酸(AZA) and the remarkable benefits it has on our skin? Chemically, it is a dicarboxylic acid, and is an acid that is much weaker than vinegar! It is naturally derived from grains and has excellent benefits to the skin! This ingredient is a favorite of ours because of its versatility and gentleness! Azelaic acid has been show to be effective against acne, 酒渣鼻, hyperpigmentation (dark spots), 是一种温和的去角质剂!

壬二酸  is one of those amazing NATURAL skincare ingredients that have a plethora of skin benefits. But while it may not be the first ingredient you have heard of, you should know what makes it great!

1. 壬二酸(AZA) 对祛痘有效.

Acne is known to be caused by four primary processes acting together – abnormally high rate of of growth of the skin cells and overproduction of the protein keratin that the skin cells produce, leading to the clogging of the skin pores (hyperkeratinisation), increased sebum/oil levels, 增加的数量 P.曼秀雷敦, a bacteria that causes acne and inflammation. Interestingly, AZA has been shown to be able to target a few of these processes at once. 例如, AZA prevents comedones from forming by decreasing the amount of keratin produced by skin cells as well as reducing the rate at which the skin cells grow (Mayer-da-Silva et al., 1989). AZA also kills the bacteria that infect pores, including those that are resistant to antibiotics, and helps to reduce the swelling caused by acne. 与类, topical use of AZA is considered safe in pregnancy and is also found to be moderately safe for use during lactation!

2. 壬二酸 softens dark spots and improves hyperpigmentation

酪氨酸酶, an enzyme responsible for the browning of fruits and vegetables, is also found in skin melanocytes and is the key enzyme responsible for producing our skin pigment, 黑色素. Excess 黑色素 production in some parts of the skin as compared to the surrounding areas leads to dark spots. It is therefore important to regulate the melanocytes and the process of 黑色素 production by tyrosinase when dealing with 皮肤色素沉着问题.

Azelaic acids SAFELY depigments the skin by preventing tyrosinase activity as well as by selectively suppressing the growth of abnormal melanocytes (Nguyen & Bui, 1995). Given its ability to reduce the darkening of the skin, it is no wonder that AZA is also the go-to choice for acne treatment as acne and scarring often lead to skin hyperpigmentation.

3. AZA reduces skin inflammation/Rosacea

Rosacea is a common skin condition thought to be primarily an inflammatory disorder. Recent data suggests that 酒渣鼻 is caused by abnormal over-activity of the enzymes found on our skin, leading to the release of skin peptides that promotes inflammation (Yamasaki et al., 2011, p. 2). Topical application of Azelaic acid has been scientifically demonstrated to reduce activity of these skin enzymes and reduce inflammation. This can help to reverse these changes, thereby reducing the unpleasant swelling and redness experienced by those with 酒渣鼻 (Coda et al., 2013).

Given the amazing benefits that AZA provides, it is no wonder that it is the highlight in our newest product– our 天然AZA洁面乳! Designed to soothe and moisturize, while at the same time heal and protect your skin, this is a creamy cleanser that also features many other natural ingredients including avocado oil, green tea extract and vegetable glycerin. 感兴趣? Contact us today to learn more!

参考文献
1. Coda,. B.，哈塔，T.米勒，J.奥迪许，D.， Kotol, P.二、A.沙菲克，F.山崎，K.哈珀，J。. C.德尔·罗索，J. Q., & 盖洛,R. L. (2013). 抗菌肽, 激肽释放酶5, and serine protease activity is inhibited during treatment of 酒渣鼻 with azelaic acid 15% gel. Journal of the American Academy of Dermatology, 69(4), 570–577. http://doi.org/10.1016/j.jaad.2013.05.019
2. Mayer-da-Silva,.戈尔尼克，H.德玛尔，M.[J].解析:选A.m., & Orfanos C. E. (1989). Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. Acta Dermato-Venereologica. 补编，143,20-30.
3. 阮,问. H., & 中方通过T. P. (1995). Azelaic acid: Pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. International Journal of Dermatology, 34(2), 75–84. http://doi.org/10.1111/j.1365-4362.1995.tb03583.x
4. 山崎裕K.，加拿大，K.麦克劳德，D. T.博科夫斯基，A. W.莫里赞，S.中津二，T.Cogen, A. L., & 盖洛,R. L. (2011). TLR2 expression is increased in 酒渣鼻 and stimulates enhanced serine protease production by keratinocytes. The Journal of Investigative Dermatology, 131(3), 688–697. http://doi.org/10.1038 / jid.2010.351